The sci-fi actioner is set 400 years in the future, when disease has wiped out the majority of the earth's population in all but one walled, protected city-state - Bregna, ruled by a congress of scientists.

Aeon Flux (Theron), is the top operative in the underground 'Monican' rebellion, led by The Handler (Frances McDormand). When Aeon is sent on a mission to kill a government leader, she uncovers a world of secrets.